Two items on the Hamilton Depression rating scale are effective predictors of remission: Comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine
Two items on the Hamilton Depression rating scale are effective predictors of remission: Comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine
Abstract
Investigated whether the responses on 2 items of the Hamilton Depression (HAM-D) scale, Depressed Mood and Psychic Anxiety, were predictive of remission of depression in placebo-controlled studies following treatment with venlafaxine or selective serotonin reuptake inhibitors (SSRIs). Data from 8 active- and placebo-controlled studies consisting of 2,027 subjects (Ss) who met the DSM-III-R/-IV criteria for major depressive disorder were analyzed. Three treatment groups were compared: venlafaxine (n=843), SSRI (n=743) and placebo (n=441). Treatment duration was 6-8 wks. Ss who scored zero on the depressed mood and the psychic anxiety items of the HAM-D₁₇ scale were designated as responders. These 2 scores were also combined to create an Absence of Depressive and Anxious Mood (ADAM) score. Between-group rate comparisons in outcome measures were carried out using Fisher's exact test and logistic regression models. Venlafaxine treatment improved depressed mood, psychic anxiety and ADAM scores after 2 wks with greater efficacy than treatment with SSRls or placebo. ADAM scores could also predict the odds ratio of a patient achieving a clinical remission. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
Accession Number: 2002-06775-004. PMID: 12409680 Partial author list: First Author & Affiliation: Silverstone, P. H.; U Alberta, Dept of Psychiatry, Edmonton, AB, Canada. Release Date: 20021204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Major Depression; Rating Scales; Remission (Disorders); Serotonin Reuptake Inhibitors. Minor Descriptor: Anxiety; Depression (Emotion); Norepinephrine; Prediction; Serotonin Norepinephrine Reuptake Inhibitors; Venlafaxine; Reuptake. Classification: Clinical Psychological Testing (2224). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2002.
